Lupus, hydroxychloroquine and breastfeeding

It seems that many more women with chronic illnesses are having babies and breastfeeding. I have

included a chapter in the second edition of Breastfeeding and Medication on this. This fact sheet on lupus and hydroxychloroquine whilst breastfeeding is taken from the book, due to be published May 2018

Lupus and hydroxychloroquine and bf

Tranexamic acid to treat heavy periods experienced by breastfeeding mothers

One of the advantages of breastfeeding is that for many it may be months or even years before menstrual bleeding returns regularly. However, some mothers do experience heavy flow which needs to be treated. Tranexamic acid is usually the drug of choice at a dose of 1 g 3 times a day for up to 4 days, to be initiated when menstruation has started; maximum 4 g per day (BNF 2018). Mothers can continue to breastfeed as normal. There is one reported case of restless in the baby in a study of 21 mothers but in general it seems anecdotally, to cause few problems.

tranexamic acid and bf

Breastfeeding and labarynthitis/vertigo

I am frequently asked about taking prochlorperazine (Buccastem® or Stemetil ®) to treat nausea due to labarynthitis, vertigo or dizziness. It is a drug I would be happy to prescribe and have used it myself as have my two breastfeeding daughters. It seems a frequently asked question when the air pressure changes rapidly.

prochlorperazine and bf

 

Pain relief when breastfeeding

It is not acceptable to leave any mother in pain because she is breastfeeding nor to suggest that she could have more effective pain relief if she stopped breastfeeding.

I’m often asked about the safety of opioids during breastfeeding so this is a really interesting study

Despite opioids being used first line in emergency settings to treat severe acute extremity pain, there is limited evidence available to inform this practice.

In a study in JAMA (7 November 2017), researchers randomly assigned 416 patients in the emergency department with moderate-to-severe acute extremity pain to one of the following groups: 400mg ibuprofen/1000mg paracetamol; 5mg oxycodone/325mg paracetamol; 5mg hydrocodone/300mg paracetamol; or 30mg codeine/300mg paracetamol[1].

https://jamanetwork.com/journals/jama/article-abstract/2661581?redirect=true

 

https://breastfeedingnetwork.org.uk/wp-content/dibm/analgesics%20and%20breastfeeding.pdf

Pee and Poo Chart

During my presentation to LLL Ireland I was asked where was it possible to obtain a copy of the pee and poo chart I mentioned. This is from my book The importance of Dads and Grandmas to the Breastfeeding Mum. Hope it helps Mums, Dads and Grandparents keep track of adequate breastfeeds and output to ensure the baby is getting enough milk.

If there are not as many pees and poos you need to call for help from an expert in breastfeeding sooner rather than later to check the attachment is as good as it can be and baby is taking milk.

 

A diary of pees and poos taken from

Webinar on Breastfeeding and Medication

We recorded these talks as live for the LLL Ireland conference to which I was unable to travel due to the weather but hope that means more people can share the information

La Leche League of Ireland

Online version of the LLL of Ireland 2018 conference featuring Drs. Wendy Jones and Kathleen Kendall-Tackett.

Posted by Kathy Kendall-Tackett on Saturday, March 3, 2018

 

webinar on the importance of others to the breastfeeding mum

La Leche League of Ireland

Online version of the LLL of Ireland 2018 conference featuring Drs. Wendy Jones and Kathleen Kendall-Tackett.

Posted by Kathy Kendall-Tackett on Saturday, March 3, 2018

Low dose aspirin and breastfeeding

low dose aspirin and breastfeeding

Norethisterone and Breastfeeding

norethisterone and bf

February is Raynaud’ s Awareness month www.sruk.co.uk/

Raynaud’s phenomenon affects up to 10% of otherwise healthy women aged 21-50 years of age. It is 9 times more common in women than men.

Yet many doctors are unaware that Raynaud’s can affect breastfeeding. It produces deep pain after feeds with a mother often automatically covering her nipples or massaging them to restore the blood flow. Symptoms are often mis-diagnosed as thrush when in fact the use of fluconazole can make the symptoms worse by causing further vasoconstriction.

Most mothers who experience problems with Raynaud’s during breastfeeding, have a history of cold hands and feet or a close relative who has. It may be that in a family it is routine to wear thick socks and gloves, maybe a vest without realising that they may be “unusual” in their response to the cold.

Babies of mothers with Raynaud’s may be born early and / or smaller because of restriction of blood flow to the placenta. It is not uncommon for there to be a maternal (or close family) history of migraines.

Symptoms which differentiate Raynaud’s phenomenon with other causes of breast pain are:

  • Pain in both breasts after feeds
  • Pain which may be precipitated by being cold or for example going down the freezer aisle in a supermarket
  • Rapid 3 colour change in the nipples after feeds
  • Pain that is resolved by warmth or gentle massage
  • A history or close family history of poor circulation

 

Treatment of Raynaud’s during breastfeeding

  • Don’t ignore the fact that pain after breastfeeds may be due to less than perfect attachment of the baby at the breast. A white tip to the nipple after feeds is not the same as the tri colour change typical of Raynaud’s
  • Nifedipine 30mg a day (either as 10mg three times a day or long acting 30mg once daily. The amount in breastmilk is too small to affect babies although it may give the mother hot flushes and / or headaches. The following extract is taken from Breastfeeding and Medication 2nd Ed to be published May 2018
  • High doses of vitamin B6 (Newman 2012), magnesium (Smith 1960, Turlapaty Leppert1994), calcium (DiGiacomo 1989), fatty acids (Belch 1985) and fish oil supplementation (DiGiacomo 1989) have also been suggested but take a minimum of 6 weeks to be effective. Ginger 2000mg-4000mg daily. Capsules usually contain 500mg. It may also be beneficial to add ginger to your diet, to drink ginger tea, or to put a spoonful of ground ginger in your bathing water (Royal Free hospital www.royalfree.nhs.uk/pip_admin/docs/Raynaudsnatural_186.pdf)

 

Nifedipine           ☺

Nifedipine relaxes vascular smooth muscle and dilates coronary and peripheral arteries. It has activity in reducing blood pressure and in the treatment of Reynaud’s syndrome

Nifedipine is almost completely absorbed from the GI tract but undergoes extensive first-pass metabolism. It is up to 98% bound to plasma proteins. It is used to treat hypertension (Penny and Lewis 1989; Ehrenkranz et al. 1989) and also to improve circulation in Reynaud’s disease (cold extremities and nipple vasospasm) in doses up to 30 mg daily (Lawlor-Smith and Lawlor-Smith 1996; Garrison 2002; Anderson et al. 2004). Side effects for the mother include flushing and headache, which may limit its usefulness. It is present in breastmilk but in levels too small to be harmful and there have been no reports of adverse effects in babies (see Chapter 5).

In Taddio et al’s study (1996) of 21 women taking 40 mg daily the babies were estimated to be exposed to 0.1% of the maternal weight adjusted dose via breastmilk. Nifedipine is widely used to treat pre-eclampsia and eclampsia in the mother together with methyldopa or a beta blocker. Ehrenkranz et al. (1989) studied one woman who took 10, 20 or 30 mg three times daily on different days. Using the maximum dose transferred by the 30 mg regimen, the authors estimated that the baby would be exposed to the authors estimated that an exclusively breastfed infant would receive an estimated maximum of 7.5 µg per kilogramme of nifedipine daily. Its relative infant dose is quoted as 2.3–3.4% (Hale 2017 online access).

The BNF reports that the amount secreted into breastmilk is too small to be harmful but that manufacturer advises it should be avoided.

Compatible with breastfeeding.

References

  • Anderson JE, Held N, Wright K, Raynaud’s phenomenon of the nipple: a treatable cause of painful breastfeeding, Pediatrics, 2004;113(4):e360–4.
  • Ehrenkranz RA, Ackerman BA, Hulse JD, Nifedipine transfer into human milk, J Pediatr, 1989;114:478–80.
  • Garrison CP, Nipple vasospasm, Raynaud’s syndrome, and nifedipine, J Hum Lact, 2002;18(4):382–5.
  • Lawlor-Smith LS, Lawlor-Smith CL, Raynaud’s phenomenon of the nipple: a preventable cause of breastfeeding failure?, Med J Aust, 1996;166:448. Letter.
  • Penny WJ, Lewis MJ, Nifedipine is excreted in human milk, Eur J Clin Pharmacol, 1989;36:427–8.
  • Taddio A; Oskamp M; Ito S; Bryan H; Farine D; Ryan D; Koren G,. Is nifedipine use during labour and breastfeeding safe for the neonate?, Clin Invest Med, 1996;19(4 Suppl.):S11. Abstract.